Stadium: Dunn-Oliver Acadome
Home Manager: Mo Williams Away Manager: Bucky McMillan
| NCAAB | 2021/12/05 20:00 | Belmont v Samford | L | 85-73 |
| NCAAB | 2021/12/01 01:00 | Samford v Mississippi College | W | 83-58 |
| NCAAB | 2021/11/27 18:30 | McNeese State v Samford | W | 75-83 |
| NCAAB | 2021/11/26 16:00 | Samford v North Carolina A&T | W | 77-75 |
| NCAAB | 2021/11/19 02:00 | Samford v Oregon State | W | 78-77 |
| NCAAB | 2021/11/16 02:00 | Samford v San Francisco | L | 55-77 |
| NCAAB | 2021/11/12 00:00 | Samford v Spring Hill | W | 86-69 |
| NCAAB | 2021/11/10 00:00 | Samford v Maryville Scots | W | 99-78 |
| NCAAB | 2021/12/02 00:00 | Alabama State v Dayton | L | 54-93 |
| NCAAB | 2021/11/28 20:30 | North Alabama v Alabama State | L | 81-69 |
| NCAAB | 2021/11/23 01:00 | Alabama State v Tuskegee | W | 91-65 |
| NCAAB | 2021/11/21 01:00 | North Carolina Central v Alabama State | W | 74-80 |
| NCAAB | 2021/11/19 00:00 | Alabama State v Iowa | L | 82-108 |
| NCAAB | 2021/11/17 01:00 | Alabama State v Iowa State | L | 60-68 |
| NCAAB | 2021/11/14 01:00 | Alabama State v Missouri State | L | 60-78 |
| NCAAB | 2021/11/11 01:00 | Alabama State v Vanderbilt | L | 72-91 |