Stadium: Leavey Center
Home Manager: Herb Sendek Away Manager: Todd Golden
| NCAAB | 2022/01/30 00:00 | Santa Clara v San Francisco | W | 85-88 |
| NCAAB | 2021/01/22 03:00 | San Francisco v Santa Clara | W | 73-50 |
| NCAAB | 2020/02/14 02:00 | San Francisco v Santa Clara | W | 70-61 |
| NCAAB | 2020/01/10 04:00 | Santa Clara v San Francisco | W | 61-80 |
| NCAAB | 2019/02/24 04:00 | San Francisco v Santa Clara | L | 65-68 |
| NCAAB | 2019/02/10 04:00 | Santa Clara v San Francisco | W | 72-78 |
| NCAAB | 2018/02/04 04:00 | San Francisco v Santa Clara | W | 70-59 |
| NCAAB | 2018/01/19 04:00 | Santa Clara v San Francisco | L | 65-62 |
| NCAAB | 2022/02/11 04:00 | Pepperdine v San Francisco | W | 61-105 |
| NCAAB | 2022/02/09 03:00 | Portland v San Francisco | L | 69-68 |
| NCAAB | 2022/02/06 01:00 | San Francisco v Portland | W | 74-71 |
| NCAAB | 2022/02/04 03:00 | San Francisco v BYU | W | 73-59 |
| NCAAB | 2022/01/30 00:00 | Santa Clara v San Francisco | W | 85-88 |
| NCAAB | 2022/01/28 03:00 | Saint Mary's CA v San Francisco | L | 72-70 |
| NCAAB | 2022/01/23 00:30 | San Francisco v Pepperdine | W | 71-45 |
| NCAAB | 2022/01/21 04:00 | San Francisco v Gonzaga | L | 62-78 |
| NCAAB | 2022/02/09 04:00 | Saint Mary's CA v Santa Clara | W | 72-77 |
| NCAAB | 2022/02/06 00:00 | Santa Clara v San Diego | W | 79-66 |
| NCAAB | 2022/02/04 02:00 | Loyola Marymount v Santa Clara | W | 60-79 |
| NCAAB | 2022/02/01 02:00 | Pacific v Santa Clara | W | 59-81 |
| NCAAB | 2022/01/30 00:00 | Santa Clara v San Francisco | L | 85-88 |
| NCAAB | 2022/01/28 04:00 | BYU v Santa Clara | W | 76-77 |
| NCAAB | 2022/01/25 02:00 | San Diego v Santa Clara | W | 74-78 |
| NCAAB | 2022/01/21 02:00 | Santa Clara v Saint Mary's CA | L | 65-73 |