Stadium: Hard Rock Hotel Riviera Maya
Home Manager: Travis Ford Away Manager: Dan Muller
| NCAAB | 2021/11/21 00:00 | Bucknell v Illinois St | W | 100-105 |
| NCAAB | 2021/11/17 01:00 | Murray State v Illinois St | L | 77-65 |
| NCAAB | 2021/11/12 23:00 | Illinois St v Eastern Michigan | L | 98-103 |
| NCAAB | 2021/11/10 01:00 | UNC Wilmington v Illinois St | W | 63-68 |
| NCAAB | 2021/03/05 02:08 | Illinois St v Northern Iowa | L | 60-65 |
| NCAAB | 2021/02/27 23:00 | Northern Iowa v Illinois St | L | 94-87 |
| NCAAB | 2021/02/27 02:00 | Northern Iowa v Illinois St | L | 70-56 |
| NCAAB | 2021/02/19 00:00 | Illinois St v Bradley | W | 88-71 |
| NCAAB | 2021/11/20 22:00 | Mercer v St Louis | W | 58-75 |
| NCAAB | 2021/11/17 01:00 | St Louis v Memphis | L | 74-90 |
| NCAAB | 2021/11/13 01:00 | Eastern Illinois v St Louis | W | 44-86 |
| NCAAB | 2021/11/11 01:00 | St Louis v Harris Stowe | W | 127-54 |
| NCAAB | 2021/11/10 01:00 | Central Arkansas v St Louis | W | 61-96 |
| NIT | 2021/03/20 21:00 | Mississippi State v St Louis | L | 74-68 |
| NCAAB | 2021/03/06 23:00 | St Louis v St. Bonaventure | L | 53-71 |
| NCAAB | 2021/03/05 18:00 | Massachusetts v St Louis | W | 72-86 |