Stadium: Chaifetz Arena
Home Manager: Travis Ford Away Manager: Greg Gary
| NCAAB | 2021/11/17 00:00 | Mercer v Life University Running Eagles | W | 78-50 |
| NCAAB | 2021/11/13 19:00 | Mercer v Winthrop | L | 85-88 |
| NCAAB | 2021/11/10 01:00 | Mercer v Arkansas | L | 61-74 |
| NCAAB | 2021/03/09 00:00 | Mercer v NC Greensboro | L | 61-69 |
| NCAAB | 2021/03/08 00:30 | Mercer v VMI | W | 73-59 |
| NCAAB | 2021/03/06 22:30 | Mercer v Wofford | W | 62-61 |
| NCAAB | 2021/03/06 01:00 | Samford v Mercer | W | 59-87 |
| NCAAB | 2021/02/27 18:00 | Mercer v Western Carolina | L | 61-85 |
| NCAAB | 2021/11/17 01:00 | St Louis v Memphis | L | 74-90 |
| NCAAB | 2021/11/13 01:00 | Eastern Illinois v St Louis | W | 44-86 |
| NCAAB | 2021/11/11 01:00 | St Louis v Harris Stowe | W | 127-54 |
| NCAAB | 2021/11/10 01:00 | Central Arkansas v St Louis | W | 61-96 |
| NIT | 2021/03/20 21:00 | Mississippi State v St Louis | L | 74-68 |
| NCAAB | 2021/03/06 23:00 | St Louis v St. Bonaventure | L | 53-71 |
| NCAAB | 2021/03/05 18:00 | Massachusetts v St Louis | W | 72-86 |
| NCAAB | 2021/03/01 23:00 | Massachusetts v St Louis | W | 57-78 |