[131] Louisville 57-63 Notre Dame [125] 2022-02-10 00:00
Stadium: Purcell Pavilion
Home Manager: Mike Brey Away Manager: Mike Pegues
Head to Head
| NCAAB | 2022/01/22 21:00 | Notre Dame v Louisville | L | 82-70 |
| NCAAB | 2021/02/24 00:00 | Notre Dame v Louisville | W | 57-69 |
| NCAAB | 2020/01/11 19:00 | Louisville v Notre Dame | W | 67-64 |
| NCAAB | 2019/03/13 23:00 | Notre Dame v Louisville | W | 53-75 |
| NCAAB | 2019/03/03 18:30 | Notre Dame v Louisville | W | 61-75 |
| NCAAB | 2018/01/17 00:00 | Louisville v Notre Dame | W | 82-78 |
| NCAAB | 2017/03/04 19:00 | Notre Dame v Louisville | W | 64-71 |
| NCAAB | 2017/01/05 02:00 | Louisville v Notre Dame | L | 70-77 |
Home History
| NCAAB | 2022/02/05 19:00 | Louisville v Syracuse | L | 69-92 |
| NCAAB | 2022/02/02 01:00 | North Carolina v Louisville | L | 90-83 |
| NCAAB | 2022/01/29 17:00 | Duke v Louisville | L | 74-65 |
| NCAAB | 2022/01/25 00:00 | Louisville v Virginia | L | 52-64 |
| NCAAB | 2022/01/22 21:00 | Notre Dame v Louisville | L | 82-70 |
| NCAAB | 2022/01/20 00:00 | Boston College v Louisville | W | 54-67 |
| NCAAB | 2022/01/15 21:00 | Louisville v Pittsburgh | L | 53-65 |
| NCAAB | 2022/01/13 02:00 | NC State v Louisville | L | 79-63 |
Away History
| NCAAB | 2022/02/05 20:00 | Notre Dame v NC State | W | 69-57 |
| NCAAB | 2022/02/03 00:00 | Notre Dame v Miami Florida | W | 68-64 |
| NCAAB | 2022/02/01 00:00 | Duke v Notre Dame | L | 57-43 |
| NCAAB | 2022/01/29 23:00 | Virginia v Notre Dame | W | 65-69 |
| NCAAB | 2022/01/27 02:00 | NC State v Notre Dame | W | 65-73 |
| NCAAB | 2022/01/22 21:00 | Notre Dame v Louisville | W | 82-70 |
| NCAAB | 2022/01/17 19:30 | Notre Dame v Howard | W | 71-68 |
| NCAAB | 2022/01/15 23:00 | Notre Dame v Virginia Tech | L | 73-79 |