Stadium: Freedom Hall Civic Center
Home Manager: Desmond Oliver Away Manager: Everick Sullivan
| NCAAB | 2021/12/02 00:30 | East Tenn St v UAB | L | 56-70 |
| NCAAB | 2021/11/27 21:00 | Lees-McRae v East Tenn St | W | 74-92 |
| NCAAB | 2021/11/25 01:00 | Kent State v East Tenn St | W | 51-57 |
| NCAAB | 2021/11/24 01:00 | East Tenn St v Missouri State | W | 77-76 |
| NCAAB | 2021/11/22 22:30 | East Tenn St v Murray State | W | 66-58 |
| NCAAB | 2021/11/19 00:00 | USC Upstate v East Tenn St | W | 43-56 |
| NCAAB | 2021/11/14 17:00 | East Tenn St v Tennessee | L | 62-94 |
| NCAAB | 2021/11/12 23:30 | East Tenn St v Appalachian State | L | 67-69 |
| NCAAB | 2021/02/18 01:00 | Lenoir Rhyne v UVa-Wise | L | 70-71 |
| NCAAB | 2021/02/13 21:30 | Lenoir Rhyne v Anderson | L | 79-80 |
| NCAAB | 2021/01/23 21:15 | Coker v Lenoir Rhyne | W | 64-75 |
| NCAAB | 2021/01/21 01:00 | Lenoir Rhyne v Wingate | W | 86-85 |
| NCAAB | 2021/01/18 19:00 | Lenoir Rhyne v Queens University | W | 71-66 |
| NCAAB | 2021/01/16 21:30 | Carson-Newman v Lenoir Rhyne | L | 73-54 |
| NCAAB | 2021/01/13 23:30 | UVa-Wise v Lenoir Rhyne | W | 63-98 |
| NCAAB | 2021/01/09 21:30 | Lenoir Rhyne v Lincoln Memorial | W | 89-83 |