Stadium: The Pavilion at Ole Miss
Home Manager: Kermit Davis Away Manager: Bucky McMillan
| NCAAB | 2021/12/19 00:00 | Kennesaw State v Samford | W | 84-85 |
| NCAAB | 2021/12/12 00:00 | Alabama A&M v Samford | W | 50-52 |
| NCAAB | 2021/12/09 00:00 | Samford v Alabama State | W | 74-64 |
| NCAAB | 2021/12/05 20:00 | Belmont v Samford | L | 85-73 |
| NCAAB | 2021/12/01 01:00 | Samford v Mississippi College | W | 83-58 |
| NCAAB | 2021/11/27 18:30 | McNeese State v Samford | W | 75-83 |
| NCAAB | 2021/11/26 16:00 | Samford v North Carolina A&T | W | 77-75 |
| NCAAB | 2021/11/19 02:00 | Samford v Oregon State | W | 78-77 |
| NCAAB | 2021/12/18 23:30 | Dayton v Mississippi | W | 68-76 |
| NCAAB | 2021/12/16 00:30 | Middle Tenn St v Mississippi | W | 52-62 |
| NCAAB | 2021/12/12 01:30 | Western Kentucky v Mississippi | L | 71-48 |
| NCAAB | 2021/12/04 17:00 | Memphis v Mississippi | W | 63-67 |
| NCAAB | 2021/12/01 00:30 | Rider v Mississippi | W | 51-75 |
| NCAAB | 2021/11/26 21:00 | Mississippi Valley State v Mississippi | W | 58-73 |
| NCAAB | 2021/11/21 18:00 | Boise State v Mississippi | L | 60-50 |
| NCAAB | 2021/11/20 02:30 | Mississippi v Elon | W | 74-56 |