Stadium: The Buc Dome
Home Manager: Barclay Radebaugh Away Manager: Steve Masiello
| NCAAB | 2021/12/11 22:00 | Manhattan v Utah | L | 62-96 |
| NCAAB | 2021/12/05 19:00 | Quinnipiac v Manhattan | L | 90-73 |
| NCAAB | 2021/12/04 00:00 | Manhattan v Siena | W | 77-72 |
| NCAAB | 2021/12/01 00:00 | Fairleigh Dickinson v Manhattan | W | 73-78 |
| NCAAB | 2021/11/20 23:00 | Manhattan v Liberty | W | 76-60 |
| NCAAB | 2021/11/20 00:30 | North Alabama v Manhattan | W | 51-55 |
| NCAAB | 2021/11/16 00:00 | Manhattan v Old Dominion | L | 58-79 |
| NCAAB | 2021/11/13 00:00 | Fordham v Manhattan | W | 60-66 |
| NCAAB | 2021/12/17 01:00 | Tennessee State v Charleston Southern | L | 78-75 |
| NCAAB | 2021/12/06 01:00 | Charleston Southern v Tarleton State | W | 59-57 |
| NCAAB | 2021/12/03 01:00 | Jacksonville v Charleston Southern | L | 67-56 |
| NCAAB | 2021/11/28 21:00 | Charleston Southern v Kennesaw State | L | 52-89 |
| NCAAB | 2021/11/26 19:00 | Charleston Southern v Clemson | L | 59-91 |
| NCAAB | 2021/11/23 00:00 | Charleston Southern v Georgia Tech | L | 70-85 |
| NCAAB | 2021/11/20 20:00 | Charleston Southern v Bob Jones University | W | 119-63 |
| NCAAB | 2021/11/18 00:00 | Charleston Southern v Wake Forest | L | 59-95 |