Stadium: Alumni Coliseum McBrayer Arena
Home Manager: A.W. Hamilton Away Manager: Matthew Driscoll
| NCAAB | 2022/01/20 17:00 | North Florida v Florida State | L | 73-86 |
| NCAAB | 2022/01/18 00:00 | Kennesaw State v North Florida | L | 62-60 |
| NCAAB | 2022/01/15 22:00 | Jacksonville v North Florida | L | 54-51 |
| NCAAB | 2022/01/12 00:00 | North Florida v Liberty | L | 56-71 |
| NCAAB | 2022/01/08 22:00 | Stetson v North Florida | L | 68-66 |
| NCAAB | 2022/01/06 00:30 | North Florida v Florida Gulf Coast | L | 67-74 |
| NCAAB | 2021/12/18 19:00 | North Florida v Trinity Baptist | W | 92-44 |
| NCAAB | 2021/12/11 19:00 | Austin Peay v North Florida | W | 84-91 |
| NCAAB | 2022/01/19 00:00 | Lipscomb v Eastern Kentucky | W | 72-86 |
| NCAAB | 2022/01/16 00:00 | Jacksonville St v Eastern Kentucky | L | 76-65 |
| NCAAB | 2022/01/12 00:00 | Eastern Kentucky v North Alabama | L | 75-76 |
| NCAAB | 2022/01/09 00:00 | Eastern Kentucky v Bellarmine | L | 61-66 |
| NCAAB | 2022/01/05 00:00 | Central Arkansas v Eastern Kentucky | L | 79-72 |
| NCAAB | 2021/12/31 20:00 | Eastern Kentucky v Alice Lloyd | W | 106-52 |
| NCAAB | 2021/12/19 00:00 | Northern Kentucky v Eastern Kentucky | W | 68-81 |
| NCAAB | 2021/12/16 00:00 | Eastern Kentucky v Midway | W | 121-67 |