Stadium: Beeghly Center
Home Manager: Jerrod Calhoun Away Manager: Brian Barone
| NCAAB | 2021/11/20 00:45 | Niagara v SIU Edwardsville | L | 70-60 |
| NCAAB | 2021/11/16 00:00 | SIU Edwardsville v Knox | W | 75-37 |
| NCAAB | 2021/11/13 01:00 | SIU Edwardsville v Chicago St | L | 56-67 |
| NCAAB | 2021/11/10 01:30 | SIU Edwardsville v Marquette | L | 77-88 |
| NCAAB | 2021/03/04 01:00 | SIU Edwardsville v Belmont | L | 61-78 |
| NCAAB | 2021/02/27 23:00 | SE Missouri State v SIU Edwardsville | L | 69-63 |
| NCAAB | 2021/02/25 23:00 | Tennessee Martin v SIU Edwardsville | W | 53-66 |
| NCAAB | 2021/02/22 23:00 | Morehead State v SIU Edwardsville | L | 56-48 |
| NCAAB | 2021/11/19 22:00 | St. Thomas (MN) v Youngstown State | W | 75-79 |
| NCAAB | 2021/11/13 23:30 | Youngstown State v SE Missouri State | W | 97-79 |
| NCAAB | 2021/11/11 01:30 | Youngstown State v Penn State | L | 59-75 |
| NCAAB | 2021/03/03 00:30 | Youngstown State v Oakland | L | 83-87 |
| NCAAB | 2021/02/26 01:00 | Illinois-Chicago v Youngstown State | W | 58-74 |
| NCAAB | 2021/02/20 22:00 | IU Indianapolis v Youngstown State | W | 70-77 |
| NCAAB | 2021/02/19 22:00 | IU Indianapolis v Youngstown State | L | 72-70 |
| NCAAB | 2021/02/13 22:00 | IPFW v Youngstown State | W | 70-72 |