Stadium: Dahlberg Arena
Home Manager: Jay Ladner Away Manager: Takayo Siddle
| NCAAB | 2021/11/21 20:00 | Lamar v Southern Miss | W | 75-82 |
| NCAAB | 2021/11/16 01:00 | Southern Miss v TCU | L | 51-83 |
| NCAAB | 2021/11/13 01:00 | UL Lafayette v Southern Miss | L | 66-45 |
| NCAAB | 2021/11/10 01:00 | Southern Miss v William Carey | W | 81-67 |
| NCAAB | 2021/03/10 01:00 | Southern Miss v Rice | L | 52-61 |
| NCAAB | 2021/02/27 22:00 | Florida Atlantic v Southern Miss | L | 73-66 |
| NCAAB | 2021/02/27 01:00 | Florida Atlantic v Southern Miss | L | 69-60 |
| NCAAB | 2021/02/20 00:00 | Southern Miss v Florida Intl | W | 85-72 |
| NCAAB | 2021/11/20 21:00 | UNC Wilmington v Delaware State | W | 67-63 |
| NCAAB | 2021/11/19 00:00 | Coastal Carolina v UNC Wilmington | W | 53-65 |
| NCAAB | 2021/11/17 00:00 | UNC Wilmington v Pittsburgh | L | 51-59 |
| NCAAB | 2021/11/13 00:00 | UNC Wilmington v Guilford | W | 77-68 |
| NCAAB | 2021/11/10 01:00 | UNC Wilmington v Illinois St | L | 63-68 |
| NCAAB | 2021/03/07 00:00 | UNC Wilmington v William & Mary | L | 60-73 |
| NCAAB | 2021/02/27 23:00 | Elon v UNC Wilmington | L | 80-77 |
| NCAAB | 2021/01/31 18:00 | Hofstra v UNC Wilmington | L | 89-83 |