Stadium: First Bank and Trust Arena
Home Manager: Eric Henderson Away Manager: Byron Smith
| NCAAB | 2021/11/28 03:00 | Prairie View v Loyola Marymount | L | 80-83 |
| NCAAB | 2021/11/18 02:00 | Prairie View v Grand Canyon | L | 64-91 |
| NCAAB | 2021/11/16 01:00 | Prairie View v Texas Tech | L | 49-84 |
| NCAAB | 2021/11/14 20:00 | Prairie View v Oklahoma State | L | 59-72 |
| NCAAB | 2021/11/14 01:00 | Prairie View v Michigan | L | 49-77 |
| NCAAB | 2021/11/12 03:30 | Prairie View v San Francisco | L | 76-92 |
| NCAAB | 2021/11/10 03:00 | Prairie View v Saint Mary's CA | L | 68-87 |
| NCAAB | 2021/03/13 23:00 | Texas Southern v Prairie View | L | 80-61 |
| NCAAB | 2021/11/25 02:30 | George Mason v South Dakota State | W | 76-80 |
| NCAAB | 2021/11/24 02:30 | Washington v South Dakota State | L | 87-76 |
| NCAAB | 2021/11/23 00:00 | Nevada v South Dakota State | W | 75-102 |
| NCAAB | 2021/11/19 02:15 | South Dakota State v Presentation College Saints | W | 99-62 |
| NCAAB | 2021/11/18 01:00 | Montana State v South Dakota State | W | 74-91 |
| NCAAB | 2021/11/14 20:00 | South Dakota State v Stephen F Austin | W | 83-71 |
| NCAAB | 2021/11/13 01:00 | South Dakota State v Alabama | L | 88-104 |
| NCAAB | 2021/11/10 02:15 | Bradley v South Dakota State | W | 65-81 |