Stadium: Jenny Craig Pavilion
Home Manager: Sam Scholl Away Manager: John Smith
| NCAAB | 2021/12/03 03:00 | Cal Poly SLO v California Baptist | L | 55-64 |
| NCAAB | 2021/11/24 20:00 | Cal Poly SLO v Idaho | W | 67-63 |
| NCAAB | 2021/11/22 20:00 | Cal Poly SLO v Nicholls State | L | 72-75 |
| NCAAB | 2021/11/20 02:00 | Cal Poly SLO v Santa Clara | L | 57-87 |
| NCAAB | 2021/11/16 03:00 | Sacramento State v Cal Poly SLO | L | 58-57 |
| NCAAB | 2021/11/12 22:00 | North Dakota State v Cal Poly SLO | L | 60-57 |
| NCAAB | 2021/11/10 03:00 | Cal Poly SLO v Westcliff University | W | 86-53 |
| NCAAB | 2021/03/12 01:00 | Cal Poly SLO v UC Irvine | L | 51-58 |
| NCAAB | 2021/12/02 03:00 | San Diego v Fresno St | L | 43-63 |
| NCAAB | 2021/11/28 23:00 | CS Northridge v San Diego | L | 56-52 |
| NCAAB | 2021/11/26 20:30 | Illinois-Chicago v San Diego | W | 52-64 |
| NCAAB | 2021/11/25 18:30 | South Alabama v San Diego | L | 68-67 |
| NCAAB | 2021/11/20 03:00 | CS Fullerton v San Diego | L | 57-55 |
| NCAAB | 2021/11/18 03:30 | Cal Riverside v San Diego | W | 62-74 |
| NCAAB | 2021/11/16 02:00 | San Diego v California | L | 70-75 |
| NCAAB | 2021/11/13 03:00 | San Diego v Nevada | W | 75-68 |