Stadium: The Pavilion at Ole Miss
Home Manager: Kermit Davis Away Manager: Barclay Radebaugh
| NCAAB | 2021/11/10 00:00 | Charleston Southern v Johnson & Wales (NC) | W | 118-71 |
| NCAAB | 2021/02/22 23:00 | Charleston Southern v Presbyterian | W | 78-77 |
| NCAAB | 2021/02/19 23:00 | Longwood v Charleston Southern | L | 64-58 |
| NCAAB | 2021/02/19 00:00 | Longwood v Charleston Southern | L | 70-62 |
| NCAAB | 2021/02/12 23:00 | Charleston Southern v High Point | W | 69-68 |
| NCAAB | 2021/02/11 23:00 | Charleston Southern v High Point | L | 73-77 |
| NCAAB | 2021/01/30 22:30 | Charleston Southern v Campbell | L | 67-75 |
| NCAAB | 2021/01/30 00:30 | Charleston Southern v Campbell | L | 58-59 |
| NCAAB | 2021/11/10 00:30 | New Orleans v Mississippi | W | 61-82 |
| NIT | 2021/03/20 01:00 | Louisiana Tech v Mississippi | L | 70-61 |
| NCAAB | 2021/03/13 02:30 | Mississippi v LSU | L | 73-76 |
| NCAAB | 2021/03/12 02:00 | SC Gamecocks v Mississippi | W | 59-76 |
| NCAAB | 2021/03/07 00:00 | Vanderbilt v Mississippi | W | 46-56 |
| NCAAB | 2021/03/03 02:00 | Kentucky v Mississippi | W | 62-70 |
| NCAAB | 2021/02/27 20:30 | Mississippi v Vanderbilt | L | 70-75 |
| NCAAB | 2021/02/24 02:00 | Mississippi v Missouri | W | 60-53 |