Stadium: Lawrence Joel Veterans Memorial Coliseum
Home Manager: Steve Forbes Away Manager: Barclay Radebaugh
| NCAAB | 2021/11/13 00:00 | Charleston Southern v Mississippi | L | 68-93 |
| NCAAB | 2021/11/10 00:00 | Charleston Southern v Johnson & Wales (NC) | W | 118-71 |
| NCAAB | 2021/02/22 23:00 | Charleston Southern v Presbyterian | W | 78-77 |
| NCAAB | 2021/02/19 23:00 | Longwood v Charleston Southern | L | 64-58 |
| NCAAB | 2021/02/19 00:00 | Longwood v Charleston Southern | L | 70-62 |
| NCAAB | 2021/02/12 23:00 | Charleston Southern v High Point | W | 69-68 |
| NCAAB | 2021/02/11 23:00 | Charleston Southern v High Point | L | 73-77 |
| NCAAB | 2021/01/30 22:30 | Charleston Southern v Campbell | L | 67-75 |
| NCAAB | 2021/11/13 00:30 | Western Carolina v Wake Forest | W | 75-87 |
| NCAAB | 2021/11/11 00:00 | William & Mary v Wake Forest | W | 59-77 |
| NCAAB | 2021/03/10 00:00 | Wake Forest v Notre Dame | L | 77-80 |
| NCAAB | 2021/03/06 01:00 | Georgia Tech v Wake Forest | L | 75-63 |
| NCAAB | 2021/03/02 23:00 | Wake Forest v Pittsburgh | L | 57-70 |
| NCAAB | 2021/02/27 21:00 | Wake Forest v Virginia Tech | L | 46-84 |
| NCAAB | 2021/02/24 21:30 | Clemson v Wake Forest | L | 60-39 |
| NCAAB | 2021/02/20 19:00 | NC State v Wake Forest | L | 80-62 |