Stadium: Wisdom Gym
Home Manager: Eric Gillespie Away Manager: Barclay Radebaugh
| NCAAB | 2021/12/03 01:00 | Jacksonville v Charleston Southern | L | 67-56 |
| NCAAB | 2021/11/28 21:00 | Charleston Southern v Kennesaw State | L | 52-89 |
| NCAAB | 2021/11/26 19:00 | Charleston Southern v Clemson | L | 59-91 |
| NCAAB | 2021/11/23 00:00 | Charleston Southern v Georgia Tech | L | 70-85 |
| NCAAB | 2021/11/20 20:00 | Charleston Southern v Bob Jones University | W | 119-63 |
| NCAAB | 2021/11/18 00:00 | Charleston Southern v Wake Forest | L | 59-95 |
| NCAAB | 2021/11/13 00:00 | Charleston Southern v Mississippi | L | 68-93 |
| NCAAB | 2021/11/10 00:00 | Charleston Southern v Johnson & Wales (NC) | W | 118-71 |
| NCAAB | 2021/11/30 03:00 | Tarleton State v Gonzaga | L | 55-64 |
| NCAAB | 2021/11/25 00:00 | Tarleton State v Michigan | L | 54-65 |
| NCAAB | 2021/11/23 01:00 | Tarleton State v North Dakota State | L | 53-54 |
| NCAAB | 2021/11/20 01:00 | Tarleton State v Paul Quinn College | W | 69-42 |
| NCAAB | 2021/11/17 01:00 | Tarleton State v Wichita State | L | 51-65 |
| NCAAB | 2021/11/13 01:00 | Tarleton State v Kansas | L | 62-88 |
| NCAAB | 2021/11/10 03:00 | Tarleton State v Stanford | L | 50-62 |
| NCAAB | 2021/03/07 01:00 | Tarleton State v UT-Rio Grande Valley | W | 69-58 |