Stadium: Robert A. Mott Gymnasium
Home Manager: John Smith Away Manager: Eric Olen
| NCAAB | 2022/01/28 03:00 | Cal Poly SLO v UC San Diego | L | 59-55 |
| NCAAB | 2005/11/18 12:00 | Cal Poly SLO v UC San Diego | L | 71-67 |
| NCAAB | 2022/03/04 03:00 | UC San Diego v CS Bakersfield | W | 72-70 |
| NCAAB | 2022/02/26 21:00 | CS Fullerton v UC San Diego | W | 76-81 |
| NCAAB | 2022/02/25 03:00 | UC San Diego v Long Beach State | L | 87-103 |
| NCAAB | 2022/02/18 03:00 | Hawaii v UC San Diego | L | 65-53 |
| NCAAB | 2022/02/16 03:00 | UC Irvine v UC San Diego | L | 56-50 |
| NCAAB | 2022/02/12 21:00 | Cal Riverside v UC San Diego | W | 62-85 |
| NCAAB | 2022/02/05 21:00 | UC San Diego v UC Santa Barbara | L | 48-84 |
| NCAAB | 2022/02/04 03:00 | UC San Diego v CS Northridge | W | 83-77 |
| NCAAB | 2022/03/04 03:00 | UC Irvine v Cal Poly SLO | W | 54-65 |
| NCAAB | 2022/02/25 05:00 | Cal Poly SLO v Hawaii | L | 54-63 |
| NCAAB | 2022/02/23 03:00 | CS Bakersfield v Cal Poly SLO | L | 61-60 |
| NCAAB | 2022/02/20 01:00 | Cal Poly SLO v Cal Riverside | L | 58-78 |
| NCAAB | 2022/02/13 03:00 | UC Santa Barbara v Cal Poly SLO | L | 69-64 |
| NCAAB | 2022/02/11 03:00 | CS Northridge v Cal Poly SLO | L | 83-78 |
| NCAAB | 2022/02/06 00:00 | Cal Poly SLO v Long Beach State | L | 65-78 |
| NCAAB | 2022/02/04 03:00 | Cal Poly SLO v CS Fullerton | L | 50-61 |