Stadium: War Memorial Gymnasium
Home Manager: Todd Golden Away Manager: Bucky McMillan
| NCAAB | 2021/11/12 00:00 | Samford v Spring Hill | W | 86-69 |
| NCAAB | 2021/11/10 00:00 | Samford v Maryville Scots | W | 99-78 |
| NCAAB | 2021/03/06 01:00 | Samford v Mercer | L | 59-87 |
| NCAAB | 2021/02/18 00:00 | Samford v Furman | L | 64-78 |
| NCAAB | 2021/02/13 18:00 | Samford v VMI | L | 56-85 |
| NCAAB | 2021/02/11 01:00 | Mercer v Samford | L | 77-70 |
| NCAAB | 2021/02/09 00:00 | Samford v Mercer | L | 82-89 |
| NCAAB | 2021/01/21 01:00 | Chattanooga v Samford | L | 70-64 |
| NCAAB | 2021/11/14 01:30 | Davidson v San Francisco | W | 60-65 |
| NCAAB | 2021/11/12 03:30 | Prairie View v San Francisco | W | 76-92 |
| NCAAB | 2021/11/10 03:30 | LIU Brooklyn v San Francisco | W | 64-98 |
| NCAAB | 2021/03/06 02:00 | San Francisco v Loyola Marymount | L | 66-70 |
| NCAAB | 2021/03/05 02:00 | San Diego v San Francisco | W | 51-67 |
| NCAAB | 2021/02/28 03:00 | San Francisco v Pacific | L | 69-76 |
| NCAAB | 2021/02/26 02:00 | San Francisco v BYU | L | 73-79 |
| NCAAB | 2021/02/19 02:00 | Loyola Marymount v San Francisco | L | 68-63 |