Stadium: Sanford Coyote Sports Center
Home Manager: Todd Lee Away Manager: Sean Woods
| NCAAB | 2021/11/17 01:00 | Southern v Rice | L | 63-81 |
| NCAAB | 2021/11/13 17:30 | Southern v Tulane | W | 73-70 |
| NCAAB | 2021/11/10 03:00 | Southern v Louisville | L | 60-72 |
| NCAAB | 2021/03/12 02:30 | Southern v Grambling State | L | 67-72 |
| NCAAB | 2021/03/06 21:00 | Southern v Texas Southern | L | 74-80 |
| NCAAB | 2021/03/05 01:30 | Southern v Prairie View | L | 61-68 |
| NCAAB | 2021/02/27 22:30 | Alcorn State v Southern | W | 75-89 |
| NCAAB | 2021/02/24 20:30 | Alabama A&M v Southern | W | 57-73 |
| NCAAB | 2021/11/14 20:00 | South Dakota v Drake | L | 50-99 |
| NCAAB | 2021/11/11 19:30 | Air Force v South Dakota | W | 53-59 |
| NCAAB | 2021/03/09 02:45 | North Dakota State v South Dakota | L | 79-75 |
| NCAAB | 2021/03/07 02:45 | Western Illinois v South Dakota | W | 69-86 |
| NCAAB | 2021/02/28 21:30 | North Dakota State v South Dakota | L | 89-77 |
| NCAAB | 2021/02/27 21:30 | North Dakota State v South Dakota | W | 71-80 |
| NCAAB | 2021/02/20 21:30 | Oral Roberts v South Dakota | W | 84-86 |
| NCAAB | 2021/02/14 20:30 | South Dakota v North Dakota | L | 81-85 |