Stadium: Alumni Coliseum McBrayer Arena
Home Manager: A.W. Hamilton Away Manager: Mike Snell
| NCAAB | 2021/11/10 00:00 | Eastern Kentucky v Georgetown (KY) | W | 93-63 |
| NCAAB | 2021/03/06 03:30 | Eastern Kentucky v Morehead State | L | 64-67 |
| NCAAB | 2021/03/05 03:30 | Austin Peay v Eastern Kentucky | W | 67-70 |
| NCAAB | 2021/02/28 00:00 | Tennessee State v Eastern Kentucky | W | 84-89 |
| NCAAB | 2021/02/26 01:00 | Belmont v Eastern Kentucky | W | 67-81 |
| NCAAB | 2021/02/22 20:00 | Eastern Kentucky v SE Missouri State | W | 87-65 |
| NCAAB | 2021/02/20 23:00 | Eastern Kentucky v SE Missouri State | L | 72-94 |
| NCAAB | 2021/02/19 02:00 | Eastern Kentucky v Tennessee Martin | W | 89-72 |
| NCAAB | 2021/02/27 22:15 | Trevecca Nazarene v Ohio Valley | W | 70-76 |
| NCAAB | 2021/02/20 20:00 | Hillsdale Chargers v Ohio Valley | L | 107-66 |
| NCAAB | 2021/02/19 00:30 | Ohio Valley v Findlay | L | 60-76 |
| NCAAB | 2021/02/17 00:30 | Ohio Valley v Malone | L | 85-101 |
| NCAAB | 2021/02/13 20:00 | Ohio Dominican v Ohio Valley | L | 92-82 |
| NCAAB | 2021/02/09 00:30 | Ohio Valley v Ohio Dominican | W | 93-72 |
| NCAAB | 2021/02/02 22:30 | Ohio Valley v Walsh | L | 69-95 |
| NCAAB | 2021/01/30 20:00 | Ohio Valley v Tiffin Dragons | W | 78-68 |