| Colombia Regional League | 2021/10/24 17:15 | Deportivo Alexis Garcia v E.D.P IND. Medellin | D | 0-0 |
| Colombia Regional League | 2021/09/17 16:00 | Sellos Colombianos v E.D.P IND. Medellin | W | 3-5 |
| Colombia Regional League | 2021/08/21 21:10 | Sol de Oriente v E.D.P IND. Medellin | L | 2-1 |
| Colombia Regional League | 2021/07/02 17:11 | Club Deportivo La Chalaca v E.D.P IND. Medellin | W | 0-2 |
| Colombia Regional League | 2021/06/27 17:15 | E.D.P IND. Medellin v Estudiantes de Medellin | L | 0-1 |
| Colombia Regional League | 2021/03/26 16:19 | Estudiantes de Medellin v E.D.P IND. Medellin | W | 0-1 |
| Colombia Regional League | 2021/03/16 17:51 | E.D.P IND. Medellin v Talento y Vida | W | 5-1 |
| Colombia Regional League | 2021/02/05 20:24 | Inder Girardota v E.D.P IND. Medellin | W | 2-7 |
| Colombia Regional League | 2021/10/18 17:00 | Estudiantes de Medellin v Politecnico J.I.C. | L | 2-1 |
| Colombia Regional League | 2021/09/21 17:00 | Politecnico J.I.C. v Total Soccer FC | L | 3-5 |
| Colombia Regional League | 2021/09/06 17:13 | Politecnico J.I.C. v Universidad de Antioquia | D | 1-1 |
| Colombia Regional League | 2021/08/28 01:06 | Politecnico J.I.C. v Real Santuario | W | 2-1 |
| Colombia Primera C | 2021/08/26 17:00 | Politecnico J.I.C. v Real Santuario | W | 2-1 |
| Colombia Primera C | 2021/08/19 17:00 | Antioquia FC v Politecnico J.I.C. | W | 1-4 |
| Colombia Regional League | 2021/08/07 01:00 | Politecnico J.I.C. v CD Gallegol | L | 1-3 |
| Colombia Regional League | 2021/07/15 15:00 | Politecnico J.I.C. v Aguilas Doradas Reserves | D | 0-0 |