| Guatemala Liga Nacional Women | 2021/10/17 21:00 | Cobaneras FC Women v Mataquescuintla FC Women | W | 2-1 |
| Guatemala Liga Nacional Women | 2021/08/28 21:00 | Cobaneras FC Women v FC Moralense Women | D | 0-0 |
| Guatemala Liga Nacional Women | 2021/08/22 19:00 | Fray Women v Cobaneras FC Women | W | 0-1 |
| Guatemala Liga Nacional Women | 2021/08/15 16:00 | Cobaneras FC Women v FC Ixcan Women | W | 4-1 |
| Guatemala Liga Nacional Women | 2021/05/15 17:00 | Cobaneras FC Women v CSD Municipal Women | L | 2-4 |
| Guatemala Liga Nacional Women | 2021/05/09 21:00 | CSD Municipal Women v Cobaneras FC Women | D | 3-3 |
| Guatemala Liga Nacional Women | 2021/04/17 21:00 | Cobaneras FC Women v Fray Women | L | 0-1 |
| Guatemala Liga Nacional Women | 2021/03/28 21:00 | Cobaneras FC Women v Cubulco Women | W | 3-0 |
| Guatemala Liga Nacional Women | 2021/10/25 00:10 | Deportivo Mixco Women v Pares Women | W | 3-0 |
| Guatemala Liga Nacional Women | 2021/10/11 00:00 | Deportivo Mixco Women v Antigua GFC Women | L | 0-1 |
| Guatemala Liga Nacional Women | 2021/10/02 18:00 | CSD Barcena FF Women v Deportivo Mixco Women | W | 0-1 |
| Guatemala Liga Nacional Women | 2021/09/26 17:11 | Santa Lucia Cotzumalguapa Women v Deportivo Mixco Women | L | 5-1 |
| Guatemala Liga Nacional Women | 2021/09/15 17:00 | Antigua GFC Women v Deportivo Mixco Women | L | 1-0 |
| Guatemala Liga Nacional Women | 2021/09/12 15:30 | Pares Women v Deportivo Mixco Women | W | 0-2 |
| Guatemala Liga Nacional Women | 2021/08/23 00:00 | Deportivo Mixco Women v CSD Barcena FF Women | W | 2-1 |
| Guatemala Liga Nacional Women | 2021/08/16 00:00 | Deportivo Mixco Women v Santa Lucia Cotzumalguapa Women | W | 2-1 |