[14] BUF Sabres 0-5 OTT Senators [15] 2022-01-26 00:00
Stadium: Canadian Tire Centre
Home Manager: Away Manager: Don Granato
Head to Head
| NHL | 2022/01/19 00:00 | BUF Sabres v OTT Senators | W | 3-1 |
| NHL | 2020/02/19 00:30 | BUF Sabres v OTT Senators | L | 4-7 |
| NHL | 2020/01/29 00:00 | OTT Senators v BUF Sabres | L | 5-2 |
| NHL | 2019/12/24 00:30 | BUF Sabres v OTT Senators | L | 1-3 |
| NHL | 2019/11/17 00:00 | OTT Senators v BUF Sabres | W | 2-4 |
| NHL | 2019/04/04 23:00 | OTT Senators v BUF Sabres | W | 2-5 |
| NHL | 2019/03/26 23:30 | BUF Sabres v OTT Senators | L | 0-4 |
| NHL | 2018/11/03 18:00 | OTT Senators v BUF Sabres | W | 2-9 |
Home History
| NHL | 2022/01/22 18:00 | PHI Flyers v BUF Sabres | W | 3-6 |
| NHL | 2022/01/21 00:00 | DAL Stars v BUF Sabres | L | 5-4 |
| NHL | 2022/01/19 00:00 | BUF Sabres v OTT Senators | W | 3-1 |
| NHL | 2022/01/17 18:00 | DET Red Wings v BUF Sabres | L | 3-2 |
| NHL | 2022/01/16 00:00 | BUF Sabres v DET Red Wings | L | 0-4 |
| NHL | 2022/01/14 01:00 | BUF Sabres v NAS Predators | W | 4-1 |
| NHL | 2022/01/12 00:00 | TB Lightning v BUF Sabres | L | 6-1 |
| NHL | 2022/01/07 00:00 | SJ Sharks v BUF Sabres | L | 3-2 |
Away History
| NHL | 2022/01/23 23:00 | OTT Senators v CLB Blue Jackets | W | 2-1 |
| NHL | 2022/01/23 00:00 | OTT Senators v WAS Capitals | L | 2-3 |
| NHL | 2022/01/21 00:00 | OTT Senators v PIT Penguins | L | 4-6 |
| NHL | 2022/01/19 00:00 | BUF Sabres v OTT Senators | L | 3-1 |
| NHL | 2022/01/16 03:00 | OTT Senators v EDM Oilers | W | 6-4 |
| NHL | 2022/01/14 02:00 | OTT Senators v CAL Flames | W | 4-1 |
| NHL | 2022/01/02 00:00 | OTT Senators v TOR Maple Leafs | L | 0-6 |
| NHL | 2021/12/19 00:00 | OTT Senators v PHI Flyers | L | 3-4 |