Head to Head
| England EFL Cup | 2015/08/11 18:45 | Milton Keynes Dons v Leyton Orient | L | 2-1 |
| England League 1 | 2015/04/18 14:00 | Milton Keynes Dons v Leyton Orient | L | 6-1 |
| England League 1 | 2014/10/18 14:00 | Leyton Orient v Milton Keynes Dons | D | 0-0 |
Home History
| England League 2 | 2021/11/27 15:00 | Northampton v Leyton Orient | L | 1-0 |
| England League 2 | 2021/11/23 19:45 | Scunthorpe v Leyton Orient | D | 1-1 |
| England League 2 | 2021/11/20 15:00 | Leyton Orient v Sutton Utd | W | 4-1 |
| England League 2 | 2021/11/13 15:00 | Rochdale v Leyton Orient | D | 2-2 |
| England EFL Trophy | 2021/11/09 19:00 | Leyton Orient v Charlton | W | 1-0 |
| England FA Cup | 2021/11/06 15:00 | Leyton Orient v Ebbsfleet United | W | 1-0 |
| England League 2 | 2021/10/30 14:00 | Leyton Orient v Hartlepool | W | 5-0 |
| England League 2 | 2021/10/23 14:00 | Stevenage v Leyton Orient | D | 0-0 |
Away History
| England League 1 | 2021/11/27 15:00 | Morecambe v Milton Keynes Dons | W | 0-4 |
| England League 1 | 2021/11/23 19:45 | Sheff Wed v Milton Keynes Dons | L | 2-1 |
| England League 1 | 2021/11/20 15:00 | Milton Keynes Dons v Burton Albion | W | 1-0 |
| England FA Cup | 2021/11/16 19:45 | Stevenage v Milton Keynes Dons | D | 1-1 |
| England League 1 | 2021/11/13 15:00 | Milton Keynes Dons v Cambridge Utd | W | 4-1 |
| England FA Cup | 2021/11/06 15:00 | Milton Keynes Dons v Stevenage | D | 2-2 |
| England League 1 | 2021/10/30 14:00 | Crewe v Milton Keynes Dons | W | 1-4 |
| England EFL Trophy | 2021/10/26 18:00 | Milton Keynes Dons v Aston Villa U21 | L | 2-4 |