Stadium: TD Arena
Home Manager: Brad Brownell Away Manager: Mark Schmidt
| NCAAB | 2021/11/18 19:00 | St. Bonaventure v Boise State | W | 67-61 |
| NCAAB | 2021/11/14 22:00 | Canisius v St. Bonaventure | W | 60-69 |
| NCAAB | 2021/11/10 00:00 | Siena v St. Bonaventure | W | 47-75 |
| NCAAB | 2021/03/20 17:45 | St. Bonaventure v LSU | L | 61-76 |
| NCAAB | 2021/03/14 17:00 | VA Commonwealth v St. Bonaventure | W | 65-74 |
| NCAAB | 2021/03/06 23:00 | St Louis v St. Bonaventure | W | 53-71 |
| NCAAB | 2021/03/05 16:00 | Duquesne v St. Bonaventure | W | 59-75 |
| NCAAB | 2021/03/01 22:00 | Dayton v St. Bonaventure | L | 55-52 |
| NCAAB | 2021/11/18 21:30 | Clemson v Temple | W | 75-48 |
| NCAAB | 2021/11/16 00:00 | Bryant v Clemson | W | 70-93 |
| NCAAB | 2021/11/13 00:00 | Wofford v Clemson | W | 68-76 |
| NCAAB | 2021/11/10 00:00 | Presbyterian v Clemson | W | 53-64 |
| NCAAB | 2021/03/20 01:20 | Rutgers v Clemson | L | 60-56 |
| NCAAB | 2021/03/10 19:30 | Miami Florida v Clemson | L | 67-64 |
| NCAAB | 2021/03/06 17:00 | Pittsburgh v Clemson | W | 62-77 |
| NCAAB | 2021/03/03 22:00 | Clemson v Syracuse | L | 54-64 |