Stadium: TD Arena
Home Manager: Bob Huggins Away Manager: Brad Brownell
| NCAAB | 2021/11/19 19:30 | St. Bonaventure v Clemson | L | 68-65 |
| NCAAB | 2021/11/18 21:30 | Clemson v Temple | W | 75-48 |
| NCAAB | 2021/11/16 00:00 | Bryant v Clemson | W | 70-93 |
| NCAAB | 2021/11/13 00:00 | Wofford v Clemson | W | 68-76 |
| NCAAB | 2021/11/10 00:00 | Presbyterian v Clemson | W | 53-64 |
| NCAAB | 2021/03/20 01:20 | Rutgers v Clemson | L | 60-56 |
| NCAAB | 2021/03/10 19:30 | Miami Florida v Clemson | L | 67-64 |
| NCAAB | 2021/03/06 17:00 | Pittsburgh v Clemson | W | 62-77 |
| NCAAB | 2021/11/20 00:00 | Marquette v West Virginia | L | 82-71 |
| NCAAB | 2021/11/19 02:30 | Elon v West Virginia | W | 68-87 |
| NCAAB | 2021/11/13 01:30 | Pittsburgh v West Virginia | W | 59-74 |
| NCAAB | 2021/11/10 00:00 | Oakland v West Virginia | W | 53-60 |
| NCAAB | 2021/03/21 21:15 | Syracuse v West Virginia | L | 75-72 |
| NCAAB | 2021/03/20 02:32 | Morehead State v West Virginia | W | 67-84 |
| NCAAB | 2021/03/11 16:30 | Oklahoma State v West Virginia | L | 72-69 |
| NCAAB | 2021/03/06 19:00 | Oklahoma State v West Virginia | L | 85-80 |