Stadium: Alaska Airlines Arena at Hec Edmundson Pavilion
Home Manager: Mike Hopkins Away Manager: Kim English
| NCAAB | 2021/11/20 00:00 | George Mason v James Madison | L | 64-67 |
| NCAAB | 2021/11/18 00:00 | George Mason v Maryland | W | 71-66 |
| NCAAB | 2021/11/14 23:00 | Morgan State v George Mason | W | 53-90 |
| NCAAB | 2021/11/13 00:00 | Pennsylvania v George Mason | W | 66-87 |
| NCAAB | 2021/11/10 00:00 | Stony Brook v George Mason | W | 52-74 |
| NCAAB | 2021/03/05 22:30 | George Mason v Davidson | L | 67-99 |
| NCAAB | 2021/03/04 22:30 | George Washington v George Mason | W | 59-73 |
| NCAAB | 2021/02/27 21:30 | La Salle v George Mason | W | 54-89 |
| NCAAB | 2021/11/19 04:00 | Wyoming v Washington | L | 77-72 |
| NCAAB | 2021/11/16 02:00 | Texas Southern v Washington | W | 65-72 |
| NCAAB | 2021/11/12 03:30 | Northern Arizona v Washington | W | 62-73 |
| NCAAB | 2021/11/10 03:00 | Northern Illinois v Washington | L | 71-64 |
| NCAAB | 2021/03/11 00:00 | Washington v Utah | L | 95-98 |
| NCAAB | 2021/02/27 19:00 | Washington v Arizona | L | 74-75 |
| NCAAB | 2021/02/26 00:00 | Washington v Arizona State | L | 72-80 |
| NCAAB | 2021/02/24 02:00 | Washington v Arizona State | L | 64-97 |