Stadium: Kaplan Arena
Home Manager: Dane Fischer Away Manager: Matt Griggs
| NCAAB | 2021/11/24 22:00 | William & Mary v Radford | L | 54-67 |
| NCAAB | 2021/11/21 22:00 | William & Mary v Howard | L | 76-82 |
| NCAAB | 2021/11/20 22:00 | Georgia State v William & Mary | L | 77-59 |
| NCAAB | 2021/11/17 00:00 | William & Mary v Norfolk State | L | 74-91 |
| NCAAB | 2021/11/13 00:00 | American v William & Mary | L | 74-62 |
| NCAAB | 2021/11/11 00:00 | William & Mary v Wake Forest | L | 59-77 |
| NCAAB | 2021/03/07 23:00 | William & Mary v Northeastern | L | 47-63 |
| NCAAB | 2021/03/07 00:00 | UNC Wilmington v William & Mary | W | 60-73 |