Stadium: Hard Rock Hotel Riviera Maya
Home Manager: Travis Ford Away Manager: Kyle Keller
| NCAAB | 2021/11/23 23:00 | Stephen F Austin v Buffalo | W | 79-78 |
| NCAAB | 2021/11/20 00:30 | Middle Tenn St v Stephen F Austin | W | 74-87 |
| NCAAB | 2021/11/14 20:00 | South Dakota State v Stephen F Austin | L | 83-71 |
| NCAAB | 2021/11/12 00:30 | Stephen F Austin v Mary Hardin-Baylor | W | 76-63 |
| NCAAB | 2021/11/10 00:30 | Stephen F Austin v LSU Alexandria | W | 82-73 |
| NCAAB | 2021/03/06 23:00 | Stephen F Austin v Sam Houston State | W | 64-59 |
| NCAAB | 2021/03/04 02:00 | Abilene Christian v Stephen F Austin | L | 63-61 |
| NCAAB | 2021/03/01 21:00 | Stephen F Austin v Central Arkansas | W | 79-66 |
| NCAAB | 2021/11/24 01:30 | Illinois St v St Louis | W | 76-82 |
| NCAAB | 2021/11/20 22:00 | Mercer v St Louis | W | 58-75 |
| NCAAB | 2021/11/17 01:00 | St Louis v Memphis | L | 74-90 |
| NCAAB | 2021/11/13 01:00 | Eastern Illinois v St Louis | W | 44-86 |
| NCAAB | 2021/11/11 01:00 | St Louis v Harris Stowe | W | 127-54 |
| NCAAB | 2021/11/10 01:00 | Central Arkansas v St Louis | W | 61-96 |
| NIT | 2021/03/20 21:00 | Mississippi State v St Louis | L | 74-68 |
| NCAAB | 2021/03/06 23:00 | St Louis v St. Bonaventure | L | 53-71 |