Stadium: Hard Rock Hotel Riviera Maya
Home Manager: Dan Muller Away Manager: Jim Whitesell
| NCAAB | 2021/11/23 23:00 | Stephen F Austin v Buffalo | L | 79-78 |
| NCAAB | 2021/11/20 19:00 | Rider v Buffalo | W | 65-87 |
| NCAAB | 2021/11/16 01:00 | Buffalo v North Texas | W | 69-66 |
| NCAAB | 2021/11/10 23:30 | Buffalo v Michigan | L | 76-88 |
| NIT | 2021/03/19 23:00 | Buffalo v Colorado State | L | 73-75 |
| NCAAB | 2021/03/14 00:30 | Ohio v Buffalo | L | 84-69 |
| NCAAB | 2021/03/13 00:30 | Akron v Buffalo | W | 74-81 |
| NCAAB | 2021/03/11 21:00 | Miami Ohio v Buffalo | W | 63-74 |
| NCAAB | 2021/11/24 01:30 | Illinois St v St Louis | L | 76-82 |
| NCAAB | 2021/11/21 00:00 | Bucknell v Illinois St | W | 100-105 |
| NCAAB | 2021/11/17 01:00 | Murray State v Illinois St | L | 77-65 |
| NCAAB | 2021/11/12 23:00 | Illinois St v Eastern Michigan | L | 98-103 |
| NCAAB | 2021/11/10 01:00 | UNC Wilmington v Illinois St | W | 63-68 |
| NCAAB | 2021/03/05 02:08 | Illinois St v Northern Iowa | L | 60-65 |
| NCAAB | 2021/02/27 23:00 | Northern Iowa v Illinois St | L | 94-87 |
| NCAAB | 2021/02/27 02:00 | Northern Iowa v Illinois St | L | 70-56 |