Stadium: Barclays Center
Home Manager: Mike Young Away Manager: Travis Steele
| NCAAB | 2021/11/25 00:00 | Xavier v Iowa State | L | 70-82 |
| NCAAB | 2021/11/21 17:00 | Norfolk State v Xavier | W | 48-88 |
| NCAAB | 2021/11/18 23:30 | Ohio State v Xavier | W | 65-71 |
| NCAAB | 2021/11/12 23:30 | Kent State v Xavier | W | 59-73 |
| NCAAB | 2021/11/10 00:30 | Niagara v Xavier | W | 60-63 |
| NCAAB | 2021/03/10 23:00 | Butler v Xavier | L | 70-69 |
| NCAAB | 2021/03/07 02:00 | Xavier v Marquette | L | 59-66 |
| NCAAB | 2021/03/03 00:00 | Xavier v Georgetown | L | 66-72 |
| NCAAB | 2021/11/25 02:30 | Memphis v Virginia Tech | L | 69-61 |
| NCAAB | 2021/11/21 21:00 | Merrimack v Virginia Tech | W | 43-72 |
| NCAAB | 2021/11/19 01:00 | St Francis PA v Virginia Tech | W | 55-85 |
| NCAAB | 2021/11/16 00:00 | Radford v Virginia Tech | W | 39-65 |
| NCAAB | 2021/11/13 01:30 | Virginia Tech v Navy | W | 77-57 |
| NCAAB | 2021/11/10 01:00 | Maine v Virginia Tech | W | 47-82 |
| NCAAB | 2021/03/19 16:15 | Virginia Tech v Florida Gators | L | 70-75 |
| NCAAB | 2021/03/12 01:30 | North Carolina v Virginia Tech | L | 81-73 |