[24] John Isner 2-6,0-6 Jannik Sinner [10] 2021-11-26 16:45
Stadium: Pala Alpitour Round: 2 Ground: Hardcourt indoor
Head to Head
| ATP Cincinnati | 2021/08/18 19:35 | Jannik Sinner v John Isner | 7-5,6-7,4-6 |
Home History
| ATP Indian Wells | 2021/10/11 03:30 | John Isner v Yoshihito Nishioka | 6-3,6-4 |
| Laver Cup | 2021/09/25 18:50 | Alexander Zverev v John Isner | 7-6,6-7,10-5 |
| US Open | 2021/08/30 17:35 | John Isner v Brandon Nakashima | 6-7,6-7,3-6 |
| ATP Cincinnati | 2021/08/19 16:05 | John Isner v Benoit Paire | 6-7,7-6,1-6 |
| ATP Cincinnati | 2021/08/18 19:35 | Jannik Sinner v John Isner | 7-5,6-7,4-6 |
| ATP Cincinnati | 2021/08/17 17:55 | John Isner v Cameron Norrie | 4-6,7-6,6-4 |
| ATP Toronto | 2021/08/15 00:00 | Daniil Medvedev v John Isner | 6-2,6-2 |
| ATP Toronto | 2021/08/14 01:35 | John Isner v Gael Monfils | 7-6,6-4 |
Away History
| ATP World Tour Finals | 2021/11/18 20:00 | Daniil Medvedev v Jannik Sinner | 6-0,6-7,7-6 |
| ATP World Tour Finals | 2021/11/16 20:00 | Jannik Sinner v Hubert Hurkacz | 6-2,6-2 |
| ATP Stockholm | 2021/11/10 17:00 | Jannik Sinner v Andy Murray | 6-7,3-6 |
| ATP Paris | 2021/11/03 15:10 | Jannik Sinner v Carlos Alcaraz Garfia | 6-7,5-7 |
| ATP Vienna | 2021/10/30 13:30 | Frances Tiafoe v Jannik Sinner | 3-6,7-5,6-2 |
| ATP Vienna | 2021/10/29 19:40 | Casper Ruud v Jannik Sinner | 5-7,1-6 |
| ATP Vienna | 2021/10/28 14:50 | Dennis Novak v Jannik Sinner | 4-6,2-6 |
| ATP Vienna | 2021/10/27 12:00 | Reilly Opelka v Jannik Sinner | 4-6,2-6 |