Appalachian State 16-24 UL Lafayette 2021-12-04 20:30
Stadium: Cajun Field Round: 1
Home Manager: Billy Napier Away Manager: Shawn Clark
Head to Head
| NCAAF | 2021/10/12 23:30 | Appalachian St v Lafayette | L | 13-41 |
| NCAAF | 2020/12/05 01:30 | Lafayette v Appalachian St | L | 24-21 |
| NCAAF | 2019/12/07 17:00 | Lafayette v Appalachian St | W | 38-45 |
| NCAAF | 2019/10/10 00:00 | Appalachian St v Lafayette | W | 17-7 |
| NCAAF | 2018/12/01 17:00 | Lafayette v Appalachian St | W | 19-30 |
| NCAAF | 2018/10/20 19:30 | Lafayette v Appalachian St | W | 17-27 |
| NCAAF | 2017/12/02 19:30 | Lafayette v Appalachian St | W | 14-63 |
| NCAAF | 2016/10/13 00:00 | Appalachian St v Lafayette | W | 24-0 |
Home History
| NCAAF | 2021/11/27 19:30 | Georgia Southern v Appalachian St | W | 3-27 |
| NCAAF | 2021/11/20 20:30 | Appalachian St v Troy | W | 45-7 |
| NCAAF | 2021/11/13 19:30 | South Alabama v Appalachian St | W | 7-31 |
| NCAAF | 2021/11/06 18:00 | Appalachian St v Arkansas State | W | 48-14 |
| NCAAF | 2021/10/30 19:30 | UL Monroe v Appalachian St | W | 28-59 |
| NCAAF | 2021/10/20 23:30 | Coastal Carolina v Appalachian St | W | 27-30 |
| NCAAF | 2021/10/12 23:30 | Appalachian St v Lafayette | L | 13-41 |
| NCAAF | 2021/10/02 18:00 | Appalachian St v Georgia State | W | 45-16 |
Away History
| NCAAF | 2021/11/27 21:00 | UL Monroe v Lafayette | W | 16-21 |
| NCAAF | 2021/11/20 21:00 | Lafayette v Liberty | W | 42-14 |
| NCAAF | 2021/11/20 17:00 | Lafayette v Lehigh | L | 10-17 |
| NCAAF | 2021/11/13 20:30 | Lafayette v Troy | W | 35-21 |
| NCAAF | 2021/11/13 17:30 | Colgate v Lafayette | L | 20-13 |
| NCAAF | 2021/11/06 16:30 | Lafayette v Holy Cross | L | 10-35 |
| NCAAF | 2021/11/04 23:30 | Georgia State v Lafayette | W | 17-21 |
| NCAAF | 2021/10/30 16:30 | Lafayette v Georgetown | W | 24-23 |