Stadium: Benedetti–Wehrli Stadium Round: 3
| NCAAF | 2021/11/27 18:00 | North Central Illinois v Uw-La Crosse Eagles | W | 34-20 |
| NCAAF | 2021/11/13 18:00 | North Central Illinois v North Park Vikings | W | 84-6 |
| NCAAF | 2021/11/06 17:00 | Washington Bears v North Central Illinois | W | 20-59 |
| NCAAF | 2021/10/30 23:00 | Millikin Big Blue v North Central Illinois | W | 27-54 |
| NCAAF | 2021/10/23 23:00 | North Central Illinois v Illinois Wesleyan Titans | W | 55-7 |
| NCAAF | 2021/10/16 23:00 | North Central Illinois v Elmhurst Bluejays | W | 77-7 |
| NCAAF | 2021/10/09 17:00 | Carthage Red Men v North Central Illinois | W | 13-64 |
| NCAAF | 2021/10/02 18:00 | Carroll Pioneers v North Central Illinois | W | 7-62 |
| NCAAF | 2021/11/27 17:00 | Cortland Red Dragons v Rpi Engineers | W | 14-21 |
| NCAAF | 2021/11/20 17:00 | Endicott Gulls v Rpi Engineers | W | 14-20 |
| NCAAF | 2021/11/13 17:00 | Union Dutchmen v Rpi Engineers | W | 17-19 |
| NCAAF | 2021/11/13 16:00 | Union College Bulldogs v Rpi Engineers | W | 17-19 |
| NCAAF | 2021/11/06 17:00 | St Lawrence Saints v Rpi Engineers | W | 20-22 |
| NCAAF | 2021/10/30 16:00 | Rpi Engineers v Ithaca Bombers | W | 14-11 |
| NCAAF | 2021/10/16 17:00 | Hobart Statesmen v Rpi Engineers | L | 10-9 |
| NCAAF | 2021/10/09 16:00 | Rpi Engineers v Buffalo State Bengals | W | 24-16 |