| Portugal 2a Divisao | 2021/09/24 20:00 | FC Porto B v CDC Santana | L | 24-23 |
| Portugal 2a Divisao | 2021/07/10 20:00 | CDC Santana v FC Porto B | L | 24-28 |
| Portugal 2a Divisao | 2021/06/30 20:30 | CDC Santana v FC Porto B | L | 23-28 |
| Portugal 2a Divisao | 2021/05/07 20:30 | FC Porto B v CDC Santana | L | 24-18 |
| Portugal Cup | 2021/11/30 21:00 | CDC Santana v CDC Sao Paio Oleiros | W | 31-28 |
| Portugal 2a Divisao | 2021/11/27 21:00 | CDC Santana v Vitoria SC | W | 23-21 |
| Portugal 2a Divisao | 2021/11/27 21:00 | CDC Santana v Vitoria Setubal | W | 23-21 |
| Portugal 2a Divisao | 2021/11/06 21:00 | CDC Sao Paio Oleiros v CDC Santana | W | 25-28 |
| Portugal 2a Divisao | 2021/11/01 21:00 | CDC Santana v Modicus Sandim | W | 27-26 |
| Portugal 2a Divisao | 2021/10/30 14:00 | GC Santo Tirso v CDC Santana | L | 27-24 |
| Portugal 2a Divisao | 2021/10/23 20:00 | CDC Santana v AC Fafe | L | 24-26 |
| Portugal 2a Divisao | 2021/10/16 20:00 | Arsenal Andebol v CDC Santana | W | 26-31 |
| Portugal 2a Divisao | 2021/11/23 21:30 | FC Porto B v Boavista FC | W | 28-25 |
| Portugal 2a Divisao | 2021/11/12 21:30 | FC Porto B v Arsenal Andebol | D | 25-25 |
| Portugal 2a Divisao | 2021/11/09 21:00 | Vitoria SC v FC Porto B | W | 27-28 |
| Portugal 2a Divisao | 2021/11/01 15:00 | FC Porto B v Maritimo Madeira | W | 31-26 |
| Portugal 2a Divisao | 2021/10/30 20:00 | AA Sao Mamede v FC Porto B | W | 24-26 |
| Portugal 2a Divisao | 2021/10/26 19:45 | FC Porto B v CDC Sao Paio Oleiros | W | 23-21 |
| Portugal 2a Divisao | 2021/10/15 20:30 | Modicus Sandim v FC Porto B | L | 29-22 |
| Portugal 2a Divisao | 2021/10/08 20:30 | FC Porto B v GC Santo Tirso | L | 21-31 |