Stadium: Gate City Bank Field at the Fargodome Round: 1
Home Manager: Matt Entz Away Manager: Randy Sanders
| NCAAF | 2021/12/04 19:00 | Kennesaw State v East Tennessee State | W | 31-32 |
| NCAAF | 2021/11/20 18:00 | Mercer v East Tennessee State | W | 35-38 |
| NCAAF | 2021/11/13 19:00 | East Tennessee State v Western Carolina | W | 56-35 |
| NCAAF | 2021/11/06 17:00 | VMI v East Tennessee State | W | 20-27 |
| NCAAF | 2021/10/23 18:00 | East Tennessee State v Furman | W | 17-13 |
| NCAAF | 2021/10/16 17:30 | East Tennessee State v Tennessee Chattanooga | L | 16-21 |
| NCAAF | 2021/10/09 20:30 | The Citadel v East Tennessee State | W | 21-48 |
| NCAAF | 2021/10/02 19:30 | Wofford v East Tennessee State | W | 21-27 |
| NCAAF | 2021/12/04 20:30 | SO Illinois v North Dakota State | W | 7-38 |
| NCAAF | 2021/11/20 20:30 | South Dakota v North Dakota State | W | 24-52 |
| NCAAF | 2021/11/13 17:00 | North Dakota State v Youngstown State | W | 49-17 |
| NCAAF | 2021/11/06 19:00 | North Dakota State v South Dakota State | L | 19-27 |
| NCAAF | 2021/10/30 19:30 | Indiana State v North Dakota State | W | 2-44 |
| NCAAF | 2021/10/23 19:30 | Missouri St v North Dakota State | W | 20-27 |
| NCAAF | 2021/10/16 19:00 | North Dakota State v Illinois State | W | 20-0 |
| NCAAF | 2021/10/09 18:00 | Northern Iowa v North Dakota State | W | 20-34 |