South Carolina State 31-10 Jackson State 2021-12-18 17:00
Stadium: Mercedes-Benz Stadium Round: 1
Home Manager: Deion Sanders Away Manager: Oliver Pough
Home History
| NCAAF | 2021/11/20 19:00 | South Carolina State v Norfolk State | W | 31-21 |
| NCAAF | 2021/11/13 18:30 | North Carolina A&T v South Carolina State | L | 27-17 |
| NCAAF | 2021/11/06 18:00 | Howard v South Carolina State | W | 12-15 |
| NCAAF | 2021/10/30 18:00 | South Carolina State v North Carolina Central | W | 27-24 |
| NCAAF | 2021/10/23 18:00 | South Carolina State v Delaware State | W | 13-7 |
| NCAAF | 2021/10/16 17:30 | Morgan State v South Carolina State | W | 14-37 |
| NCAAF | 2021/10/09 22:00 | South Carolina State v Florida A&M | L | 7-30 |
| NCAAF | 2021/10/02 17:30 | Bethune Cookman v South Carolina State | W | 35-42 |
Away History
| NCAAF | 2021/12/04 21:00 | Prairie View v Jackson State | W | 10-27 |
| NCAAF | 2021/11/20 19:00 | Alcorn State v Jackson State | W | 10-24 |
| NCAAF | 2021/11/14 00:00 | Jackson State v Southern | W | 21-17 |
| NCAAF | 2021/11/06 18:00 | Texas Southern Tigers v Jackson State | W | 21-41 |
| NCAAF | 2021/10/30 20:00 | Jackson State v Mississippi Valley State | W | 28-19 |
| NCAAF | 2021/10/23 18:00 | Bethune Cookman v Jackson State | W | 12-42 |
| NCAAF | 2021/10/16 19:00 | Alabama State v Jackson State | W | 7-28 |
| NCAAF | 2021/10/09 19:00 | Jackson State v Alabama | W | 61-15 |