[22] Iowa State 13-20 Clemson [22] 2021-12-29 22:45
Stadium: Camping World Stadium Round: 312
Home Manager: Matt Campbell Away Manager: Dabo Swinney
Home History
| NCAAF | 2021/11/26 21:30 | TCU v Iowa State | W | 14-48 |
| NCAAF | 2021/11/20 17:00 | Iowa State v Oklahoma | L | 21-28 |
| NCAAF | 2021/11/13 20:30 | Iowa State v Texas Tech | L | 38-41 |
| NCAAF | 2021/11/06 23:30 | Texas v Iowa State | W | 7-30 |
| NCAAF | 2021/10/30 18:00 | Iowa State v West Virginia | L | 31-38 |
| NCAAF | 2021/10/23 19:30 | Oklahoma State v Iowa State | W | 21-24 |
| NCAAF | 2021/10/16 23:30 | Iowa State v Kansas State | W | 33-20 |
| NCAAF | 2021/10/02 23:00 | Kansas v Iowa State | W | 7-59 |
Away History
| NCAAF | 2021/11/28 00:30 | Clemson v South Carolina | W | 30-0 |
| NCAAF | 2021/11/20 17:00 | Wake Forest v Clemson | W | 27-48 |
| NCAAF | 2021/11/13 17:00 | Connecticut v Clemson | W | 7-44 |
| NCAAF | 2021/11/06 23:30 | Clemson v Louisville | W | 30-24 |
| NCAAF | 2021/10/30 19:30 | Florida State v Clemson | W | 20-30 |
| NCAAF | 2021/10/23 19:30 | Clemson v Pittsburgh | L | 17-27 |
| NCAAF | 2021/10/15 23:00 | Clemson v Syracuse | W | 17-14 |
| NCAAF | 2021/10/02 23:30 | Boston College v Clemson | W | 13-19 |