Stadium: James Work Memorial Stadium Round: 8
| NCAAF | 2021/11/20 17:00 | Delaware Valley Aggies v Anna Maria Amcats | W | 62-10 |
| NCAAF | 2021/11/13 17:00 | Delaware Valley Aggies v Widener Pride | W | 27-0 |
| NCAAF | 2021/11/06 17:00 | Wilkes Colonels v Delaware Valley Aggies | W | 0-30 |
| NCAAF | 2021/10/30 17:00 | Delaware Valley Aggies v Lebanon Valley Flying Dutchmen | W | 31-3 |
| NCAAF | 2021/10/23 17:00 | Misericordia Cougars v Delaware Valley Aggies | W | 0-35 |
| NCAAF | 2021/10/16 16:00 | Fdu Florham Devils v Delaware Valley Aggies | W | 7-61 |
| NCAAF | 2021/10/09 17:00 | Delaware Valley Aggies v Kings Monarchs | W | 48-15 |
| NCAAF | 2021/10/02 17:00 | Lycoming Warriors v Delaware Valley Aggies | W | 7-32 |
| NCAAF | 2021/11/20 17:00 | Muhlenberg Mules v Framingham State Rams | W | 45-0 |
| NCAAF | 2021/11/13 17:00 | Muhlenberg Mules v Moravian Greyhounds | W | 55-0 |
| NCAAF | 2021/11/06 17:00 | Susquehanna Crusaders v Muhlenberg Mules | W | 27-52 |
| NCAAF | 2021/10/30 17:00 | Franklin And Marshall Diplomats v Muhlenberg Mules | W | 10-27 |
| NCAAF | 2021/10/23 16:00 | Muhlenberg Mules v Juniata Eagles | W | 56-16 |
| NCAAF | 2021/10/15 23:00 | Muhlenberg Mules v Johns Hopkins Blue Jays | W | 21-6 |
| NCAAF | 2021/10/02 17:00 | Gettysburg Bullets v Muhlenberg Mules | W | 19-54 |
| NCAAF | 2021/09/25 18:00 | Mcdaniel Green Terror v Muhlenberg Mules | W | 0-23 |