Stadium: First Security Stadium Round: 8
| NCAAF | 2021/11/20 19:00 | Harding Bisons v Washburn Ichabods Football | W | 30-14 |
| NCAAF | 2021/11/13 20:00 | Arkansas Tech Wonder Boys v Harding Bisons | W | 0-31 |
| NCAAF | 2021/11/06 19:00 | Southwestern Oklahoma State Bulldogs v Harding Bisons | W | 7-55 |
| NCAAF | 2021/10/30 19:00 | Northwestern Oklahoma State Rangers v Harding Bisons | W | 14-73 |
| NCAAF | 2021/10/23 20:00 | Harding Bisons v Arkansas Monticello Boll Weevils | W | 64-7 |
| NCAAF | 2021/10/16 19:00 | Henderson State Reddies v Harding Bisons | W | 21-46 |
| NCAAF | 2021/10/09 19:00 | Harding Bisons v Southern Nazarene | W | 49-10 |
| NCAAF | 2021/10/02 19:00 | Oklahoma Baptist Bison v Harding Bisons | W | 7-31 |
| NCAAF | 2021/11/20 19:00 | NW Missouri State v Central Washington | W | 50-21 |
| NCAAF | 2021/11/13 19:30 | NW Missouri State v Emporia State | W | 35-7 |
| NCAAF | 2021/11/06 19:00 | Missouri Southern Lions v NW Missouri State | W | 7-49 |
| NCAAF | 2021/10/30 19:00 | NW Missouri State v Nebraska Kearney | W | 66-13 |
| NCAAF | 2021/10/23 18:00 | Northeastern State Riverhawks v NW Missouri State | W | 7-59 |
| NCAAF | 2021/10/16 18:00 | Washburn Ichabods Football v NW Missouri State | L | 17-16 |
| NCAAF | 2021/10/09 18:30 | NW Missouri State v Pittsburgh State Gorillas | W | 20-19 |
| NCAAF | 2021/10/02 23:00 | Missouri Western Griffons v NW Missouri State | W | 7-30 |