Stadium: Benedetti–Wehrli Stadium Round: 8
| NCAAF | 2021/11/13 18:00 | North Central Illinois v North Park Vikings | W | 84-6 |
| NCAAF | 2021/11/06 17:00 | Washington Bears v North Central Illinois | W | 20-59 |
| NCAAF | 2021/10/30 23:00 | Millikin Big Blue v North Central Illinois | W | 27-54 |
| NCAAF | 2021/10/23 23:00 | North Central Illinois v Illinois Wesleyan Titans | W | 55-7 |
| NCAAF | 2021/10/16 23:00 | North Central Illinois v Elmhurst Bluejays | W | 77-7 |
| NCAAF | 2021/10/09 17:00 | Carthage Red Men v North Central Illinois | W | 13-64 |
| NCAAF | 2021/10/02 18:00 | Carroll Pioneers v North Central Illinois | W | 7-62 |
| NCAAF | 2021/09/25 19:00 | North Central Illinois v Augustana Augie | W | 58-6 |
| NCAAF | 2021/11/20 17:00 | Albion Britons v Uw-La Crosse Eagles | W | 23-58 |
| NCAAF | 2021/11/13 17:30 | Uw-La Crosse Eagles v Uw-Eau Claire Blugolds | W | 44-20 |
| NCAAF | 2021/11/06 18:00 | UW-Whitewater v Uw-La Crosse Eagles | L | 13-7 |
| NCAAF | 2021/10/30 18:00 | Uw-Stevens Point Pointers v Uw-La Crosse Eagles | W | 3-56 |
| NCAAF | 2021/10/23 18:00 | Uw-La Crosse Eagles v Uw-Stout Blue Devils | W | 44-38 |
| NCAAF | 2021/10/16 18:00 | Uw-Platteville Pioneers v Uw-La Crosse Eagles | W | 23-24 |
| NCAAF | 2021/10/09 19:00 | Uw-La Crosse Eagles v Wisconsin Oshkosh | W | 30-21 |
| NCAAF | 2021/10/02 18:00 | Uw-River Falls Falcons v Uw-La Crosse Eagles | W | 23-45 |