Round: 7
| NCAAF | 2021/11/13 17:00 | Muhlenberg Mules v Moravian Greyhounds | W | 55-0 |
| NCAAF | 2021/11/06 17:00 | Susquehanna Crusaders v Muhlenberg Mules | W | 27-52 |
| NCAAF | 2021/10/30 17:00 | Franklin And Marshall Diplomats v Muhlenberg Mules | W | 10-27 |
| NCAAF | 2021/10/23 16:00 | Muhlenberg Mules v Juniata Eagles | W | 56-16 |
| NCAAF | 2021/10/15 23:00 | Muhlenberg Mules v Johns Hopkins Blue Jays | W | 21-6 |
| NCAAF | 2021/10/02 17:00 | Gettysburg Bullets v Muhlenberg Mules | W | 19-54 |
| NCAAF | 2021/09/25 18:00 | Mcdaniel Green Terror v Muhlenberg Mules | W | 0-23 |
| NCAAF | 2021/09/18 17:00 | Muhlenberg Mules v Ursinus Bears | L | 35-42 |
| NCAAF | 2021/11/13 17:00 | Worcester State Lancers v Framingham State Rams | W | 21-40 |
| NCAAF | 2021/11/06 16:00 | Framingham State Rams v Bridgewater State Bears | W | 47-13 |
| NCAAF | 2021/10/30 16:00 | Massachusetts Maritime Buccaneers v Framingham State Rams | W | 14-23 |
| NCAAF | 2021/10/09 19:00 | Fitchburg State Falcons v Framingham State Rams | W | 0-35 |
| NCAAF | 2021/10/02 17:00 | Plymouth State Panthers v Framingham State Rams | W | 0-33 |
| NCAAF | 2021/09/25 16:00 | Framingham State Rams v Westfield State Owls | W | 41-6 |
| NCAAF | 2021/09/18 16:00 | Framingham State Rams v Umass Dartmouth Corsairs | W | 45-21 |
| NCAAF | 2021/09/11 16:00 | St John Fisher Cardinals v Framingham State Rams | L | 38-7 |