Round: 7
| NCAAF | 2021/11/13 18:07 | Wabash Little Giants v Depauw Tigers | L | 42-35 |
| NCAAF | 2021/11/06 17:00 | Depauw Tigers v Oberlin Yeomen | W | 66-13 |
| NCAAF | 2021/10/30 17:00 | Depauw Tigers v Denison Big Red | W | 27-10 |
| NCAAF | 2021/10/23 17:00 | Allegheny Gators v Depauw Tigers | W | 14-38 |
| NCAAF | 2021/10/16 17:00 | Depauw Tigers v Ohio Wesleyan Battling Bishops | W | 24-7 |
| NCAAF | 2021/10/09 18:00 | Wittenberg Tigers v Depauw Tigers | W | 14-17 |
| NCAAF | 2021/10/02 17:00 | Depauw Tigers v Hiram Terriers | W | 57-7 |
| NCAAF | 2021/09/25 18:00 | Wooster Scots v Depauw Tigers | W | 30-34 |
| NCAAF | 2021/11/13 18:30 | Rose Hulman Engineers v Mount St. Joseph Lions | W | 58-21 |
| NCAAF | 2021/11/06 17:30 | Franklin College Grizzlies v Rose Hulman Engineers | W | 14-38 |
| NCAAF | 2021/10/30 17:30 | Rose Hulman Engineers v Bluffton Beavers | W | 48-12 |
| NCAAF | 2021/10/23 17:30 | Manchester Spartans v Rose Hulman Engineers | W | 14-57 |
| NCAAF | 2021/10/16 17:30 | Rose Hulman Engineers v Anderson Ravens | W | 62-7 |
| NCAAF | 2021/10/09 18:00 | Rose Hulman Engineers v Hanover | W | 31-21 |
| NCAAF | 2021/10/02 17:30 | Defiance Yellow Jackets v Rose Hulman Engineers | W | 14-63 |
| NCAAF | 2021/09/18 18:00 | Hope Flying Dutchmen v Rose Hulman Engineers | L | 27-20 |