Stadium: Joseph J. Gentile Center
Home Manager: Drew Valentine Away Manager: Joe Griffin
| NCAAB | 2021/12/04 21:00 | Loyola Chicago v DePaul | W | 68-64 |
| NCAAB | 2021/12/02 01:00 | Indiana State v Loyola Chicago | W | 76-88 |
| NCAAB | 2021/11/27 00:00 | Arizona State v Loyola Chicago | W | 59-77 |
| NCAAB | 2021/11/25 19:30 | Auburn v Loyola Chicago | L | 62-53 |
| NCAAB | 2021/11/24 15:00 | Loyola Chicago v Michigan State | L | 61-63 |
| NCAAB | 2021/11/20 21:00 | Illinois-Chicago v Loyola Chicago | W | 63-80 |
| NCAAB | 2021/11/17 01:00 | Chicago St v Loyola Chicago | W | 56-92 |
| NCAAB | 2021/11/13 19:00 | Florida Gulf Coast v Loyola Chicago | W | 77-89 |