Stadium: F. G. Clark Center
Home Manager: Sean Woods Away Manager:
| NCAAB | 2021/12/08 00:00 | Southern v Kentucky | L | 64-76 |
| NCAAB | 2021/12/05 00:00 | Southern v Akron | L | 62-79 |
| NCAAB | 2021/11/28 20:00 | Southern v Tennessee State | W | 82-80 |
| NCAAB | 2021/11/23 08:27 | Southern v Ecclesia College | W | 109-53 |
| NCAAB | 2021/11/21 21:00 | Southern v Nebraska | L | 59-82 |
| NCAAB | 2021/11/20 01:00 | Southern v South Dakota | L | 68-71 |
| NCAAB | 2021/11/17 01:00 | Southern v Rice | L | 63-81 |
| NCAAB | 2021/11/13 17:30 | Southern v Tulane | W | 73-70 |