[2] FLA Panthers 6-1 BUF Sabres [6] 2022-03-08 00:00
Stadium: KeyBank Center
Home Manager: Don Granato Away Manager: Andrew Brunette
Head to Head
| NHL | 2021/12/03 00:00 | BUF Sabres v FLA Panthers | W | 4-7 |
| NHL | 2020/01/04 18:00 | FLA Panthers v BUF Sabres | L | 2-3 |
| NHL | 2019/11/24 22:00 | BUF Sabres v FLA Panthers | L | 5-2 |
| NHL | 2019/10/11 23:00 | FLA Panthers v BUF Sabres | L | 2-3 |
| NHL | 2019/02/20 00:00 | BUF Sabres v FLA Panthers | W | 2-4 |
| NHL | 2019/01/04 00:00 | FLA Panthers v BUF Sabres | L | 3-4 |
| NHL | 2018/12/19 00:00 | FLA Panthers v BUF Sabres | W | 5-2 |
| NHL | 2018/12/01 00:00 | BUF Sabres v FLA Panthers | W | 2-3 |
Home History
| NHL | 2022/03/05 23:00 | DET Red Wings v FLA Panthers | W | 2-6 |
| NHL | 2022/03/04 00:00 | OTT Senators v FLA Panthers | W | 0-3 |
| NHL | 2022/02/26 17:30 | EDM Oilers v FLA Panthers | L | 4-3 |
| NHL | 2022/02/25 00:00 | CLB Blue Jackets v FLA Panthers | L | 6-3 |
| NHL | 2022/02/23 00:00 | NAS Predators v FLA Panthers | L | 6-4 |
| NHL | 2022/02/20 20:00 | FLA Panthers v CHI Blackhawks | W | 5-2 |
| NHL | 2022/02/19 01:00 | FLA Panthers v MIN Wild | W | 6-2 |
| NHL | 2022/02/17 00:30 | FLA Panthers v CAR Hurricanes | W | 3-2 |
Away History
| NHL | 2022/03/06 18:00 | LA Kings v BUF Sabres | L | 3-0 |
| NHL | 2022/03/05 00:00 | MIN Wild v BUF Sabres | W | 4-5 |
| NHL | 2022/03/03 00:30 | BUF Sabres v TOR Maple Leafs | W | 5-1 |
| NHL | 2022/02/27 19:00 | BUF Sabres v DAL Stars | L | 2-4 |
| NHL | 2022/02/26 01:00 | BUF Sabres v STL Blues | L | 3-5 |
| NHL | 2022/02/24 00:30 | BUF Sabres v MON Canadiens | L | 0-4 |
| NHL | 2022/02/20 23:00 | BUF Sabres v CLB Blue Jackets | L | 3-7 |
| NHL | 2022/02/19 18:00 | COL Avalanche v BUF Sabres | L | 5-3 |