Head to Head
| England U23 Premier League Cup | 2021/09/02 18:00 | Arsenal U23 v Southampton U23 | D | 1-1 |
| England Premier League 2 | 2021/03/05 14:00 | Southampton U23 v Arsenal U23 | D | 2-2 |
| England Premier League 2 | 2020/09/11 14:00 | Arsenal U23 v Southampton U23 | W | 1-2 |
| England Premier League 2 | 2019/11/23 13:00 | Arsenal U23 v Southampton U23 | L | 1-0 |
| England Premier League 2 | 2017/01/16 19:00 | Southampton U23 v Arsenal U23 | L | 1-3 |
| England Premier League 2 | 2016/10/14 18:00 | Arsenal U23 v Southampton U23 | D | 0-0 |
Home History
| England Premier League 2 | 2021/12/06 16:00 | Stoke U23 v Southampton U23 | L | 3-0 |
| England Premier League 2 | 2021/11/28 14:00 | Southampton U23 v West Brom U23 | W | 3-1 |
| England U23 Premier League Cup | 2021/11/24 19:00 | Southampton U23 v Bournemouth U23 | W | 1-0 |
| England Premier League 2 | 2021/11/21 12:00 | Sunderland U23 v Southampton U23 | L | 3-2 |
| England Premier League 2 | 2021/11/05 12:00 | Southampton U23 v Newcastle U23 | W | 5-0 |
| England Premier League 2 | 2021/10/31 14:00 | Southampton U23 v Aston Villa U23 | W | 4-0 |
| England Premier League 2 | 2021/10/25 18:00 | Reading U23 v Southampton U23 | W | 0-1 |
| England Premier League 2 | 2021/10/18 11:00 | Wolverhampton U23 v Southampton U23 | W | 0-1 |
Away History
| England Premier League 2 | 2021/12/06 19:00 | Everton U23 v Arsenal U23 | L | 2-0 |
| England Premier League 2 | 2021/11/26 19:00 | Arsenal U23 v Derby U23 | L | 3-5 |
| England Premier League 2 | 2021/11/22 19:00 | Blackburn U23 v Arsenal U23 | W | 2-3 |
| England U23 Premier League Cup | 2021/11/11 19:00 | Arsenal U23 v West Brom U23 | L | 1-4 |
| England Premier League 2 | 2021/11/06 13:00 | Arsenal U23 v Leicester U23 | D | 3-3 |
| England Premier League 2 | 2021/10/29 18:00 | Leeds U23 v Arsenal U23 | W | 2-4 |
| England Premier League 2 | 2021/10/22 18:00 | Arsenal U23 v Everton U23 | W | 4-0 |
| England Premier League 2 | 2021/10/16 15:00 | Liverpool U23 v Arsenal U23 | L | 3-0 |