Stadium: G.B. Hodge Center
Home Manager: Dave Dickerson Away Manager: Ryan Saunders
| NCAAB | 2021/12/15 00:00 | USC Upstate v Tennessee | L | 52-96 |
| NCAAB | 2021/12/12 00:00 | USC Upstate v Wake Forest | L | 53-79 |
| NCAAB | 2021/12/04 23:00 | Western Carolina v USC Upstate | L | 78-73 |
| NCAAB | 2021/12/01 21:00 | North Carolina Central v USC Upstate | L | 67-65 |
| NCAAB | 2021/11/27 21:00 | Furman v USC Upstate | L | 87-77 |
| NCAAB | 2021/11/24 00:00 | USC Upstate v South Carolina State | W | 82-78 |
| NCAAB | 2021/11/19 00:00 | USC Upstate v East Tenn St | L | 43-56 |
| NCAAB | 2021/11/15 23:00 | USC Upstate v St. Andrew's | W | 96-43 |
| NCAAB | 2021/12/18 00:00 | Gardner Webb v Converse Valkyries | L | 79-46 |