Stadium: A.W. Mumford Stadium Round: 1
| NCAAF | 2016/09/11 00:00 | Tulane v Southern | L | 66-21 |
| NCAAF | 2016/09/03 23:00 | UL Monroe v Southern | L | 38-21 |
| NCAAF | 2015/09/26 16:00 | Georgia v Southern | L | 48-6 |
| NCAAF | 2015/09/05 23:00 | Louisiana Tech v Southern | L | 62-15 |
| NCAAF | 2014/08/30 23:00 | Lafayette v Southern | L | 45-6 |
| NCAAF | 2012/09/01 12:00 | New Mexico v Southern | L | 66-21 |
| NCAAF | 2009/09/05 12:00 | Lafayette v Southern | L | 42-19 |
| NCAAF | 2008/08/30 12:00 | Houston v Southern | L | 55-3 |
| NCAAF | 2016/09/17 16:00 | Clemson v South Carolina State | L | 59-0 |
| NCAAF | 2016/09/10 23:00 | Louisiana Tech v South Carolina State | L | 53-24 |
| NCAAF | 2016/09/03 23:00 | Central Florida v South Carolina State | L | 38-0 |
| NCAAF | 2014/09/06 16:30 | Clemson v South Carolina State | L | 73-7 |
| NCAAF | 2012/09/22 12:00 | Texas A&M v South Carolina State | L | 70-14 |
| NCAAF | 2012/09/15 12:00 | Arizona v South Carolina State | L | 56-0 |
| NCAAF | 2011/09/17 12:00 | Indiana v South Carolina State | L | 38-21 |
| NCAAF | 2011/09/01 12:00 | Central Michigan v South Carolina State | L | 21-6 |