Stadium: Banterra Center
Home Manager: Bryan Mullins Away Manager: Donte' Jackson
| NCAAB | 2021/12/22 01:00 | Grambling State v TCU | L | 55-90 |
| NCAAB | 2021/12/15 00:30 | Grambling State v UAB | L | 61-79 |
| NCAAB | 2021/12/11 20:30 | Grambling State v Incarnate Word | L | 62-72 |
| NCAAB | 2021/12/04 21:00 | Grambling State v Connecticut | L | 59-88 |
| NCAAB | 2021/12/03 01:00 | Grambling State v Jarvis Christian | W | 71-44 |
| NCAAB | 2021/11/29 23:00 | Norfolk State v Grambling State | L | 70-63 |
| NCAAB | 2021/11/29 03:30 | Grambling State v Morgan State | W | 74-59 |
| NCAAB | 2021/11/25 01:00 | Grambling State v Louisiana College | W | 71-61 |
| NCAAB | 2021/12/22 22:00 | Southern Illinois v San Francisco | L | 52-64 |
| NCAAB | 2021/12/18 21:00 | Southern Illinois v Maryville | W | 75-55 |
| NCAAB | 2021/12/16 01:00 | SE Missouri State v Southern Illinois | W | 55-80 |
| NCAAB | 2021/12/11 19:00 | Southern Illinois v Tulsa | L | 65-69 |
| NCAAB | 2021/12/05 02:00 | Southern Miss v Southern Illinois | W | 41-66 |
| NCAAB | 2021/12/02 00:00 | Southern Illinois v Evansville | W | 54-52 |
| NCAAB | 2021/11/27 01:00 | Alcorn State v Southern Illinois | W | 59-62 |
| NCAAB | 2021/11/22 22:45 | Creighton v Southern Illinois | L | 66-64 |